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CM-Glucan Granulate

CM-Glucan Granulate is a derivative of ß-(1,3) and ß-(1,6) glucan, a natural yeast polysaccharide featuring immune-stimulating properties. ß-Glucan that is isolated from yeast is insoluble in water and therefore not suitable for topical use. Consequently, Mibelle Biochemistry has developed a process to offer CM-Glucan Granulate, a biologically active ß-glucan derivative that maintains the same biological activity as ß-glucan, is highly purified and also water-soluble.

Numerous clinical studies have demonstrated the benefits of CM-Glucan Granulate on either very extremely sensitive skin or skin that is exposed to extreme stress, e.g. following esthetic procedures.

ß-(1-3)-glucan purified from the cell walls of common baker’s yeast is a physiologically active compound. It fights infections and is probably one of the most studied natural immunomodulators.

Mibelle Biochemistry has been a pioneer in terms of purifying ß-glucans from the cell walls of baker’s yeast and in modifying the molecule for an improved water-solubility. In CM-Glucan Forte (Magnesium Carboxymethyl Beta-Glucan ), the divalent magnesium ions enhance the structural stability of the large molecule. Moreover, Mg++ ions bind water molecules, exhibit anti-inflammatory properties and were shown to positively influence epidermal proliferation and differentiation.

Proven efficacy

In vitro

  • Inhibits the release of CGRP (->soothing effect)
  • Inhibits calcium influx into sensory neurons (->soothing effect)

In vivo

  • Strongly protects skin against dehydration after stress
  • Accelerates skin regeneration
  • Protects against UV-induced loss of firmness
  • Protects skin lipids against UV damage
  • Reduces wrinkle depth


  • Increases the skin's self-protecting capacity
  • Accelerates skin recovery
  • Restores the skin's moisture barrier

INCI (EU/PCPC) Declaration

Sodium Carboxymethyl Beta-Glucan



  • Powder
  • Water-soluble
  • Single substance
  • Without preservatives

Recommended use level

  • 0.02 – 0.1 %